Research & Publications

Research & Scientific Discoveries

Section 1: Primary Research (FM-TTFields & TTFields)

This portfolio establishes the Scientific Moat of our organization. By validating the unique mechanisms of frequency modulation and synergistic delivery, this research bridges the gap between theoretical bioelectric physics and established pre-clinical oncology, providing the evidentiary trail for the FM-TTFields platform.

A. In-Vitro Synergistic Mechanisms in Combined THerapies

Tumor-treating fields and concurrent cisplatin: an in vitro demonstration of efficacy in triple-negative breast cancer American Journal of Cancer Research | 2025

B. Optimization of Delivery With Frequency Modulation

Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation Cancer Cell International | 2023

C. Hardware Engineering & Selectivity of Effect In Vitro

Efficacy and selectivity of tumor-treating field therapy for triple-negative breast cancer cells via in-house delivery device Discover Oncology | 2023

Intellectual Property & Foundational Framework

The FM-TTFields technology platform is protected by a robust portfolio of proprietary intellectual property, including domestic and international patent filings covering our unique bioelectric algorithms and delivery systems.

Detailed patent and application data are restricted to qualified institutional partners and are available for review under a standard Non-Disclosure Agreement (NDA).

Section 2: Clinical Oncology & Radiation Research

This body of work represents over two decades of board-certified clinical expertise and technical mastery in advanced energy-tissue interactions. These publications in particle therapy and radiation physics demonstrate the Institutional-Grade authority required to translate complex energy fields into viable medical interventions.

Bringing the heavy: carbon ion therapy in the radiobiological and clinical context Radiation Oncology | 2014
Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy, and adaptive proton radiotherapy for treatment of locally advanced head and neck cancerr Radiotherapy and Oncology | 2011
Enhanced dosimetry procedures and assessment for EBT2 radiochromic film Medical Physics | 2012
Predicted rates of secondary malignancies from proton versus photon radiation therapy for stage I seminoma International Journal of Radiation Oncology* Biology* Physics | 2012
Lymphovascular invasion in prostate cancer: prognostic significance in patients treated with radiotherapy after radical prostatectomy Cancer | 2006
Fiducial markers in prostate for kV imaging: quantification of visibility and optimization of imaging condition Physics in Medicine and Biology | 2012
Improving proton therapy accessibility through seamless electronic integration of remote treatment planning sites Telemedicine and e-Health | 2011
A Hybrid Integrated Services Digital Network–Internet Protocol Solution for Resident Education Telemedicine and e-Health | 2010
Development of a remote proton radiation therapy solution over internet2 Telemedicine and e-Health | 2009

Section 3: Abstracts & Presentations

Maintaining an active presence at elite scientific symposia ensures that our technological framework is subject to ongoing peer scrutiny. These contributions represent our latest innovations presented to the American Society for Radiation Oncology (ASTRO) and the American Association for Cancer Research (AACR).

Reducing Fibrosis with Tumor Treating Fields ASTRO Annual Meeting, San Francisco, CA | 2025
Synergistic effects of next-generation Tumor-Treating Fields technology and cinnamaldehyde/cinnamon oil on apoptosis, cell cycle arrest and growth suppression in triple-negative breast cancer cells AACR Annual Meeting, San Diego, CA | 2026
Ending the HIV Epidemic with Low Dose Total Body Irradiation in Combination with Anti-Microtubule Therapy ASTRO Annual Meeting, San Francisco, CA | 2025
Dosimetric Comparison of Photon Stereotactic Ablative Radiation Therapy (SABR) and Proton SABR in the treatment of Prostate Cancer Patients ASTRO Annual Meeting, Boston, MA | 2012
Dosimetric Comparison of Parallel Opposed-Laterals versus Parallel Opposed-Laterals Plus an Anterior Field for Proton Therapy Prostate Plans ASTRO Annual Meeting, Miami Beach, FL | 2011
The Role of U.S. Military Radiation Oncologists in Modern Warfare. RSNA Annual Meeting, Chicago, IL | 2011
Five Year PSA-Failure Rates for Prostate Cancer Patients Treated with Dose-Escalated IMRT ASTRO Annual Meeting, Miami Beach, FL | 2011
Para-aortic Nodal Clinical Target Volume Delineation in the Era of Particle Therapy ASTRO Annual Meeting, Miami Beach, FL | 2011
A Comparative Study of Different Monte Carlo Modeling Techniques for Proton Dose in Biological Materials American Physical Society March Meeting, Baltimore, MD | 2006
Electronic Integration of Radiation Oncology Clinics via Remote Proton Radiotherapy Telemedicine Solution ASTRO Annual Meeting, San Diego, CA | 2010

From Research to Reality

Explore how our scientific discoveries are being engineered into a new generation of bioelectric medical devices.

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